The Cancer Gene Index Translational Medicine Use Case

The Cancer Gene Index is used as the backbone for the BioXM configured data model to integrate information from various sources into a Translational Medicine use case example. The data model connects patients (i.e. demographic-diagnosis, treatment) with biology (i.e. genes-proteins-tissue) with chemistry (i.e. chemical compounds-drugs-clinical trials) with 160+ types of cancer diseases. In 2009, Sophic used the supplemental data from an important Colon Cancer Paper published by an NCI Principle Investigator to graphically display bed to bench and bench to bed relationships. The objects in this BioXM screen image represent underlying detailed patient information that can be integrated from Electronic Health Records (EHRs) or Electronic Clinical Research Forms (ECRFs), the genes that are significantly over expressed in the cancer tissue, the compounds that suppress the gene expression, and the clinical trials on the potential drug candidates for this particular colorectal cancer.