Sophic Druggable Genome

The concept of the “druggable genome” has been used to denote a list of genes that can serve as suitable targets for developing therapeutic drugs. The term has been in vogue the last few years after the concept was first published in a key paper by Hopkins and Groom in 2002. The Hopkins & Groom list of genes and gene families has been regularly revised and updated by others (Russ and Lampel, 2005). Today, however, information on druggable genes is still scattered throughout many public databases, and there is no integrated repository where the cancer research community can access all this information.

Sophic has undertaken the Integrated Druggable Genome Database (IDGD) Project at the encouragement of NCI Principal Investigators. The aim is to provide a single repository of druggable genes that will support a wide range of cancer research initiatives. The IDGD has been generated using Sophic’s knowledge integration methods, and software tools developed by Biomax Informatics AG, Munich Germany.